Positive interference by danazol in a testosterone radioimmunoassay kit procedure.
نویسندگان
چکیده
We describe a problem in measuring serum testosterone concentrations in the serum of women who are taking danazol. The Diagnostic Products Corporation testosterone radioimmunoassay gives very high apparent testosterone concentrations in these women and the value obtained depends on the volume of serum extracted per assay tube. Chromatography of the serum extracts on Sephadex LH-20, but not on Celite, before radioimmunoassay reduced these high apparent testosterone concentrations to less than that found in normal women.
منابع مشابه
Further studies on danazol interference in testosterone radioimmunoassays.
Investigating the interference of danazol in testosterone radioimmunoassays, we measured serum testosterone concentrations in the serum of women receiving danazol, with three testosterone radioimmunoassay kits. All of these showed positive interference by danazol or its metabolites (or both). Values for testosterone obtained with two of the methods (Diagnostic Products Corp. and Farmos Diagnost...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 27 4 شماره
صفحات -
تاریخ انتشار 1981